| 학회지 검색 | HOME > 논문 및 학회지 > 학회지 검색 |
대한생식의학회지 제28권 제4호 2010년
자궁근종과 성호르몬 대사물과의 연관성
연세대학교 의과대학 산부인과학교실,한국과학기술연구원 생체대사 연구센터
배상욱, 배상욱,정병화,정봉철,전진동,이현정,권한성
Correlation between Steroid Hormone Metabolites and Leiomyomas of Uterus
Bai sw
Department of Obstetrics and Gynecology, Yonsei University College of Medicine
Objective: To elucidate 1) whether there are any differences in the urine concentrations of steroid hormone metabolites between patients with leiomyoma and normal controls 2) the correlation between urinary profiles of steroid hormones and leiomyomas of the uterus according to their type, location, volume, and weight. Materials of Methods: The study population consisted of 37 premenopausal patients with uterine leiomyoma and the control group consisted of 25 premenopausal normal volunteer women without uterine leiomyoma. Confirmation of the existence of uterine leiomyoma was done by ultrasonography and histopathological examination after surgery. The volume of the leiomyoma was estimated by trans-abdominal and/or trans-vaginal ultrasonography. The Leiomyomas were divided into 3 types (subserosal, intramural and submucosal). Seventeen patients had subserosal type of leiomyoma, 10 with the intramural type and 10 with the submucosal type. The locations of the leiomyoma were also divided into 3 groups (fundus, body and isthmus). Seventeen patients showed a fundus location, 10 in body, and 10 in isthmus. We compared urinary profiles of the endogenous steroids between patients with leiomyomas and normal controls, and also investigated the relationship between urinary profiles of the endogenous steroids and leiomyomas according to their type, location, volume and weight by using highly sensitive Gas Chromatography-Mass Spectrometry (GC-MS) system. Results: The mean ages of the patients with leiomyomas and the control group were 43.1±5.6 and 40.6±7.2 years, the weights were 63.4±7.3 and 59.4±8.1 kg, and their heights were 155.4±4.8 and 159.3±4.8 cm respectively. Seventeen patients had subserosal, 10 had intramural, and 10 had submucosal leiomyomas. There were 17 patients with leiomyoma located in fundus, 10 in body and 10 in isthmus. 17β-estradiol, 5-AT, 11-keto ET, 11β-hydroxy An, 11β-hydroxy Et, THS, THA, THE, α-cortolone, α-cortol, β-cortol, 11β-OH Et/11β-OH An and E2/E1 were significantly increased in patients with leiomyoma than in the control group. 17β-estradiol was significantly increased in the intramural and the submucosal types than in the subserosal type. There was no significant difference in the concentrations of urinary steroids according to the locations of leiomyomas. There was no significant relationship between the concentration of urinary steroids and the volume of the leiomyomas. 17β-estradiol significantly decreased as the weight of uterus increased (r=-0.322, p=0.04). Conclusion: The concentrations of steroid hormone metabolites were generally increased in patients with leiomyoma but were not significantly related to the volume and weight of the leiomyomas. Our study suggests that steroid hormones may be involved in the initiation of leiomyomas but may not be involved in their progression. In addition, the concentrations of steroid hormone metabolites are not related to the leiomyoma type and location.
키워드 : Steroid hormone metabolites, Leiomyomas
교신저자 : swbai@yumc.yonsei.ac.kr
전문 파일 : 
