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대한생식의학회지 제29권 제4호 2010년
난소적출술 환자에서 Estrogen 단독요법 및 Estrogen-androgen 병합요법에 관한 연구
서울대학교 의과대학 산부인과학교실
배광범,
A Study of Estrogen only Therapy and Estrogen Plus Androgen Combination Therapy in Surgical Menopause Patients
Bai KB
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea
Objective: To evaluate the difference between estrogen only therapy and estrogen-androgen combination therapy in surgical menopause patients. Materials and Method: Surgical menopause patients received 0.625 mg conjugated equine estrogens or 0.625 mg conjugated equine estrogens plus 1.25 mg methyltestosterone for 2 years. Bone mineral density, menopausal symptoms, lipoprotein profiles were measured. Results: Both groups showed increased bone mineral density. In the combination group, total cholesterol, high density lipoprotein cholesterol and triglycerides decreased. In the estrogen only group, low density lipoprotein cholesterol decreased but high density lipoprotein cholesterol increased significantly. In both groups, menopausal symptoms were much improved. Side effects were easily tolerated in both groups. Conclusions: Estrogen-androgen combination therapy had comparable benefits compared with estrogen only therapy.
키워드 : Estrogen-androgen therapy, Surgical menopause
교신저자 : kbbai@brm.co.kr
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