| 학회지 검색 | HOME > 논문 및 학회지 > 학회지 검색 |
대한생식의학회지 제29권 제4호 2010년
p53 Codon 72 다형성과 한국인 여성의 자궁내막증의 연관성에 관한 연구
이화여자대학교 의과대학 산부인과학교실
허성은, 심성신,이경순,문혜성,유한기,정혜원
Association Study of the Relationship between Endometriosis and Polymorphism of p53 Codon 72
Hur SE
Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University
Objective: The present study was performed to evaluate the association of p53 codon 72 polymorphism and endometriosis. Materials and Methods: We investigate 74 women who were operated for endometriosis and 93 women who had no endometriotic lesion proved by operation. Polymerase chain reaction was used to detect p53 codon polymorphisms. Result: We have found no significant difference between endometriosis and control group in the p53 codon polymorphism. The respective proportion of arginine homozygotes, heterozygotes and proline homozygotes in endometriosis group were 18.9%, 62.2% and 18.9%, respectively, and were 12.9%, 75.2% and 11.9%, respective in the group without endometriosis. Conclusion: Endometriosis is not associated with p53 polymorphism in Korean endometriosis patients.
키워드 : Endometriosis, p53, Polymorphism, Arginine, Proline
교신저자 : drsarah@ewha.ac.kr
전문 파일 : 
