| 학회지 검색 | HOME > 논문 및 학회지 > 학회지 검색 |
대한생식의학회지 제30권 제1호 2010년
체외수정시술에서 정자의 수정능력이 배아의 발생능 및 임신율에 미치는 영향
(주)젠딕스, 서울대학교 의학연구원 인구의학연구소, 인천 서울여성병원, 서울대학교 의과대학 산부인과학교실
방명걸, 정병준,문신용
Influence of Sperm Fertilizing Capacity on Embryonic Development and Pregnancy in In Vitro Fertilization
Pang MG
GenDix, Inc., Institute of Reproductive Medicine and Population, Medical Research Center
Objectives: To assess the fertilizing capacity using sperm penetration assay (SPA) to predict the outcome of the in vitro fertilization-embryo transfer (IVF-ET) outcome. Materials and Methods: Semen samples were provided by 129 patients undergoing IVF. We attempted to correlate the extent of sperm penetration under enhanced SPA protocol with the results of fertilization, cleavage, preimplantation embryo development, and pregnancy. Results: Univariate analysis demonstrated a statistically significant correlation between fertilizing capacity and motility, kinetics, fertilization, cleavage and embryo development, and pregnancy rate. By logistic regression analysis, fertilizing capacity was found to be the only variable that was statistically significant with respect to pregnancy rate. Fertilizing capacity, cleavage rate and pregnant rate were significantly higher in pregnant group. However, the fertilization rates was comparable with both group. Conclusions: Lower fertilizing capacity could denote a poorer prognosis for establishing a pregnancy, even after satisfactory fertilization rate is achieved.
키워드 : Fertilizing capacity, SPA, IVF-ET
교신저자 : shmoon@plaza.snu.ac.kr
전문 파일 : 
