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대한생식의학회지 제32권 제1호 2010년
Principle and Application of Immunotherapy in Women with Recurrent Pregnancy Losses and Infertility of Implantation Failures: Intravenous Immunoglobulin G Infusion Treatment
Department of Obstetrics and Gynecology, Department of Microbiology and Immunology, Rosalind Franklin University of Medicine and Science/The Chicago Medical School, USA
Joanne Young Hee Kwak,
.
.
Randomized double blind study has been acce- pted as the standard for clinical trials for drug efficacy in Unites States. However, IVIg treatment for recurrent pregnancy losses or infertility of im- plantation failures has its limitation for double blind randomized trial due to 1) heterogeneous nature of disease which requires significantly hi- gher number of study participants; 2) cost concern for clinical trial due to high cost of IVIg; and 3) concerns about legal issues in relation to pregn- ancy outcome from clinical trial. Clinicians need, however, to recognize the limitations of IVIg clin- ical data and have to adjust their clinical mana- gement to the degree and quality of patient evalua- tion available to them in their community. Further investigation is warranted for IVIg treatment in women with recurrent pregnancy losses and in vitro fertilization failure associated with antipho- spholipid antibodies and elevated NK cells.
키워드 :
교신저자 : Joanne.Kwak-Kim@Rosalindfranklin.edu
전문 파일 : 
