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대한생식의학회지 제32권 제1호 2010년
다낭성 난소 증후군 환자에서 Isoflavone 섭취에 따른 혈중 생화학적 지표의 변화
연세대학교 의과대학 영동세브란스병원 산부인과학교실1, 연세대학교 생활과학대학 식품영양학과2
원형재1, 강주희2, 이민준2, 윤선2, 박기현1, 조동제1, 송찬호1, 이병석1,
The Effect of Isoflavone Supplementation on Plasma Biochemical Parameters of Women with Polycystic Ovary Syndrome
Hyung Jae Won1, Ju Hee Kang2, Min Jun Lee2, Sun Yoon2, Ki Hyun Park, Dong Je Cho1, Chan Ho Song1, Byung Seok Lee1
1Department of Obstetrics and Gynecology, Yong dong Severance Hospital, Yonsei University, College of Medicine, Seoul, Korea, 2Department of Food and Nutrition, The graduate School of Yonsei University, Seoul, Korea
Objective: This study was performed to evaluate the effect of isoflavone supplementation on hormone levels, lipid profiles and total antioxidant status in patients with polycystic ovary syndrome. Methods: Total 11 women with polycystic ovary syndrome were supplemented daily with 150mg of isoflavone for 6 months. Blood samples were collected 0, 3, and 6 months after supplement of isoflavone for analysis of LH, FSH, E2, testosterone, free testosterone, SHBG levels, serum lipid profiles, and total antioxidant status (TAS). Results: After 6 months isoflavone supplementation, the hormone levels did not change significantly. Serum lipid profiles did not show any significant change in total cholesterol, LDL-cholesterol, triglyceride, lipoprotein(a), and free fatty acid levels. However, there was significant increase in HDLcholesterol (p<0.05) for 3 months. Total antioxidant status was increased significantly after isoflavone supplementation for 6 months (p<0.05). Conclusion: Isoflavone supplementation showed positive effects on the HDL-cholesterol and total antioxidant status. it is implicated that isoflavone supplementation will may have a effect on cardiovascular disease in patients with polycystic ovary syndrome.
키워드 : Isoflavone, Polycystic ovary syndrome, Hormone levels, Lipid profiles, Total antioxidant Isoflavone, Polycystic ovary syndrome, Hormone levels, Lipid profiles, Total antioxidant status
교신저자 : dr222@yumc.yonsei.ac.kr
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