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대한생식의학회지 제32권 제3호 2010년
중증 자궁내막증 환자의 내막에서 thrombospondin-1과 -2의 mRNA의 발현에 관한 연구
이화여자대학교 의과대학 산부인과학교실, 건국대학교 의과대학 산부인과학교실1
허성은, ,이지영1,문혜성,정혜원
mRNA Expression of Thrombospondin-1 and -2 in Severe Endometriosis Patients in Korean Women
Sung Eun Hur, Lee Ji Young1, Hye Sung Moon, Hye Won Chung
Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea, 1Department of Obstetrics and Gynecology, ollege of Medicine, KonKuk University, Seoul, Korea
Objective: We investigated the expression of TSP-1 and -2 in eutopic endometrium of advanced endometriosis and control patients.
Methods: The 33 endometriosis patients and 32 controls were enrolled. Endometrial samples were obtained from 65 premenopausal women aged 29-44 years, undergoing laparoscopic surgery or hysterectomy for non-malignant lesions. Sufficient samples were collected from 33 patients with endometriosis stage III and IV and 32 controls without endometriosis confirmed by laparoscopic surgery. The mRNA expression from eutopic endometrium for TSP-1 and -2 were analyzed by RT-QC PCR.
Results: The mRNAs of TSP-1 and -2 were expressed in eutopic endometrium from endometriosis and normal controls throughout the menstrual cycle. There were no significant differences in expression of TSP-1 and TSP-2 in eutopic endometrium between controls and endometriosis patients.
Conclusion: Our results indicated that TSP-1 and -2 had no crucial role compared to other molecules in the regulation of angiogenesis. These findings also suggest that dysregulation of other angiogenic regulators would be concerned in pathophysiologic role in endometriosis development.
키워드 : Thrombospondin, Endometriosis, Angiogenesis
교신저자 : hyewon@ewha.ac.kr
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