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대한생식의학회지 제35권 제1호 2010년
난소 과자극증후군과 동반된 뇌바닥동맥 혈전증
계명대학교 의과대학 산부인과교실
박준철, 임수연, 배진곤, 김종인, 이정호*,
A Case of Basilar Arterial Thrombosis in Ovarian Hyperstimulation Syndrome
Joon Cheol Park, Su Yeon Lim, Jin Gon Bae, Jong In Kim, Jeong Ho Rhee*
Department of Obstetrics and Gynecology, School of Medicine, Keimyung University, Daegu, Korea
Thromboembolic disease associated with assisted reproductive techniques is considered to be extremely rare but most serious complication. The reasons for this are thought to hypercoagulable state characteristic of OHSS due to high serum levels of estrogen, hemoconcentration and reduced circulating blood volume, but is still unclear. The risk is increased those with rare hypercoagulable conditions such as antiphospholipid antibody syndrome, protein C deficiency, protein S deficiency, antithrombin III deficiency, and those with a personal or family history of thromboembolic disease. The majority of thrombosis reported were venous site but arterial thrombosis mostly intracerebral was reported 5 cases in Korea so far. We present a case of basilar a. thrombosis at 11 days after hCG injection. The patient developed the right hemiparesis, and recovered after intraarterial thrombolysis and transluminal angioplasty. Protein S activity was decreased and vWF antigen was increased. Decreased protein S activity was also found in previous reported 4 cases, so we suggest screening test for protein S in OHSS patients.
키워드 : Ovarian hyperstimulation syndrome, Arterial thrombosis, Protein S
교신저자 : junjh55@hanmail.net
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