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대한생식의학회지 제27권 제1호 2010년
동결수정란 이식주기에서 수정란 융해 후 생존율과 임신율에 영향을 미치는 요인
성균관대학교 의과대학 삼성제일병원 생식생물학 및 불임연구실, 산부인과
김정욱, 변혜경, 염혜원, 전진현, 박용석, 송인옥1, 송지홍1, 최범채1, 궁미경1, 전종영1, 강인수1,
Analysis of Factors Affecting Survival and Pregnancy Rate in Frozen-thawed Embryo Transfers
Jeong-Wook Kim, Hye Kyung Byun, Hye Won Youm, Jin Hyun Jun, Yong-Seog Park, In Ok Song1, Ji Hong Song1, Bum Chae Choi1, Mi Kyoung Koong1, Jong Young Jun1, Inn Soo Kang1
Laboratory of Reproductive Biology & Infertility, Department of OB/GYN1 Sansung Cheil Hospital & Women’s Healthcare Center Sungkyunkwan University School of Medicine, Seoul, Korea
Objective: The purpose of this study was to determine the important factors affecting survival and pregnancy rate in frozen-thawed embryo transfer cycles. Methods: We performed retrospective analysis in 738 cycles of frozen-thawed embryo transfers, in relation to the insemination methods, the freezing stage of embryo, patient’s age, infertility factors and the origin of injected sperm in ICSI cycles. After conventional IVF or ICSI, the supermumerary PN stage zygotes or multicellular embryo were cryopreserved by slow freezing protocol with 1,2-propanediol (PROH) as a cryoprotectant. Results: The survival rates of thawed embryos were 69.3%(1585/2287) in conventional IVF group and 71.7%(1645/2295) in ICSI group. After frozen-thawed embryo transfers, 27.0%(92/341) and 32.0% (109/341) of pregnancy rates were achieved in conventional IVF and ICSI group, respectively. There were no significant difference in the survival and pregnancy rates according (36.2%) of male factor infertility was significantly higher than the tubal(27.2%) and other female factor infertility (22.9%). In ICSI group, the origin of injected sperm did not affect the outcome of frozen-thawed embryo transfer cycles. Conclusion: The present study demonstrates that acceptable clinical outcomes can e achieved after the transfer of frozen-thawed embryos regardless of the stage of emryos ofr freezing, the patient’s age and the origin of injected sperm.
키워드 : Cryopreservation, Intracytoplasmic sperm injection(ICSI), Survival rate, Pregnancy rate, Infertility factors
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