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대한생식의학회지 제27권 제1호 2010년
자궁내막증환자에서 성선자극호르몬 유리호르몬 협동제 치료후 면역인자의 변화양상
서울대학교 의과대학 산부인과학교실1, 중앙대학교 의과대학 산부인과학교실2, 성균관대학교 의과대학 산부인과학교실3, 임상병리학교실4, 제주의료원5
김정구1, 김동호2, 최두석3, 김대원4, 문신용1, 강순범1, 이용희5, 이진용1,
Changes in Profiles of Humoral Immune Facrors after Treatment of Gonadotropin Releasing Hormone Agonist in Patients with Endometriosis
Jung Gu Kim1, Dog Ho Kim2, Doo Suck Choi3, Dae Won Kim4, Shin Yong Moon1, Soong Beom Kang1, Yong Hee Lee5, Jin Yong Lee1
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University1, Department of Obstetrics and Gynecology, College of Medicine, Chung Ang University2, Department of Obstetrics and Gynecology3, Department of Clinical Pathology4, College of Medicine, Sung Geun Kwan University, Cheju Medical Center
Objectives: To investigate the incidence of antiphospholipid antibodies in patients with proven endometriosis and apparedtly normal controls, and to evaluate the changes in profiles of humoral immune factors in endometriosis after treatment with gonadotropin releasing hormone agonist (GnRHa). Methods: Sera of 92 patients with endometriosis, 40 patients without endometriosis and 128 normal male blood doners (normal controls) were tested for the presence of autoantibodies to six phosphatidic acid) and β2-glycoprotein I (GPI)- dependent anticardiolipin antibodies. Also, antiendometrial antibodies (AEA), antiphospholipid antibodies (APA), Immunoglobulin (Ig)G, IgA, IgM, complement C3, C4 and CA-125 were measured in 26 endometriosis patients before and after 3 months of GnRHa treatment. Results: Eighteen (19.6%) patients with endometriosis had at least one of the APA compared with normal controls (8.3%). The prevalence of β2-GPI- dependent anticardiolipin antibodies was higher in patients with endometriosis than in normal controls. There wer no significant changes in the positivity and levels of AEA and APA after GnRHa treatment and the levels of immunoglobulins and complement showed similar pattern. However, the numbers of patients with the level of CA-125 > 35 IU/ml, which is defined as the upper limit of normal level and the levels of CA-125 decreased. Conclusions: Around 20% of patients with endometriosis had APA and CA-125 measurement may be better than humoral factor tests in monitoring patients with endometriosis after GnRHa treatment.
키워드 : Endometriosis, Antiphospholipid antibodies, Humoral immune factors, CA-125, GnRHa
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