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대한생식의학회지 제27권 제1호 2010년
자궁내막증이 있는 불임환자에서 복강액내의 Cytokine에 관한 연구
한림대학교 의과대학 산부인과학교실, 임상병리학교실
가정배, 박제용, 김범, 김성주, 손우석, 김현태, 장봉림,
A Study of Cytokine in Peritoneal Fluid of infertile Patients with Endometriosis
Jeong-Bae Kang, Je-Yong Park, Bum Kim, Sung-Joo Kim, Woo-Seok Sohn, Hyun-Tae Kim, Pong-Rheem Jang
Department of Obstetrics and Gynecology, Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea
Objective: The presence of the various cytokines in human peritoneal fluid has been evaluated incompletely. Changes in cytokine levels may be related to activation of peritoneal macrophange and T-lymphocyte, development of endometriosis, and infertility. This syudy assesses peritoneal fluid leves of interleukim-6(IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-∝ (TNF-∝) in infertile women with endometriosis and normal women without endometriosis. Design: Prospective and case-control study in university hospital. Materials and Methods: Cytokine levels in peritoneal fluid obtained during laparotomy or laparoscopy from 21 patients in infertile patients with endometriosis and 24 controls undergoing laparotomy of laparoscopy with no evidence of pelvic endometriosis were determined by enzyme-linked immunosorbent assay. Results: The mean levels of interleukin-6 in infertile patients with endometriosis and controls were 72.2±23.7 pg/ml and 18.5±9.7 pg/ml respectively (p=0.02). Similarly, the mean levels of interleukin-8 in infertile patients with endometriosis was significantly higher than that of controls (445.0±89.6 vs 45.1±48.4, p=0.04). The mean concentration of interleukin-10 in infertile patients with endometriosis was significantly lower than that of controls (1.09±0.04 vs 2.19±0.03, p=0.03). The level of tumor necrosis factor-∝ was not significantly different between the two study groups. Conclusions: Increased IL-6 and IL-8 and decreased IL-10 levels in the peritoneal fluid may be related to pathogenesis in the endometriosis and infertility, suggesting that partially contribute to the disturbed immune regulation observed in infertili woman with endometriosis.
키워드 : Cytokine, Peritoneal fluid, Endometriosis, Infertility, Cell-mediated immune response
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