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대한생식의학회지 제27권 제3호 2010년
구형정자의 난자내 미세주입 후 보조활성화술에 의한 임신과 분만 1례
부산 마리아산부인과1, 서울 마리아산부인과2, 대구대학교 생물공학과3
주재홍1, 이용찬1, 윤산현2, 임진호2, 박흠대3,
A Normal Pregnancy and Delivery by Assisted Activation Following Round-headed Spermatozoa (Globozoospermia) Injected into Oocytes
Jaehong Joo1, Youngchan Lee1, Sanhyun Yun2, Jinho Im2, Heumdai Park3
Maria Infertility Clinic1, Pusan, Maria Infertility Clinic2, Seoul, Department of Biotechnology3, College of Engineering, Teagu University
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Globozoospermia is a rare type of teratozoospermia. It occurs in 0.1% of all andrological patient's and used to be considered sterile. Globozoospermic patient has 100% round headed spermatozoa, but the spermiogram is normal. The spermatozoa show oval-shape head, the lack of a nuclear envelope, acrosome, and post acrosomal sheath. Objective: To report that a couple with infertility secondary to globozoospermia received ICSI treatment. Material and Method: Case report Results: In the first trial, fertilization was failed. Inter second trial, 40% of oocytes were fertilized and all of these embryo were cleaved, but pregnancy did not achieved. In the third trial, sperm injected oocytes were exposed to 10 uM calcium ionophore for 15 min. All of the injected oocytes were fertilized and proceeded to develop. Triplet pregnancy was achieved after the transfer of six embryos in their third cycle. One embryo vanished and the remaining twins (female) were delivered at 33 weeks of gestation by Caesarean section. Conclusion: This result shows that assisted activation following ICSI may overcome infertility associated with globozoospermia.
키워드 : Globozoospermia, ICSI, Oocyte activation
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