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대한생식의학회지 제35권 제3호 2010년
한국인 조기난소부전 여성의 배란양상
을지대학교 의과대학 산부인과학교실
김혜민, 김재령,최은주,박은주,홍서유,이진용,박원일
Pattern of Ovulation in Korean Women with Premature Ovarian Failure
Hye Min Kim
Department of Obstetrics and Gynecology, School of Medicine, Eulji University
.
Objective: Significant portion of premature ovarian failure patients ovulate intermittently and even can achieve pregnancy. The clinical features and reproductive potentials of Korean women with premature ovarian failure have never been elucidated. The purpose of this study is to assess ovarian follicular growth and ovulatory potential. Methods: Complete medical records of fifteen women with idiopathic premature ovarian failure were reviewed retrospectively. Subjects with more than 6 ultrasonographic scans and 36 months of follow-up period were included. Once the ovarian follicle was found by ultrasonography, the follicular growth was serially monitored. The result of ovulation induction of 6 cycles in 4 patients were also evaluated. Rate of positive ovarian follicle by ultrasound, rate of natural follicular growth and response of ovulation induction were assessed. Results: Among the 15 patients, 6 women (40%) had ovarian follicle in random ultrasonography. But the chance of positive follicle per ultrasonography scan was 7% (8 out of 115 scans). One out of 6 women eventually ovulated during the follow-up scan. In remaining 5 subjects, size of follicles remained unchanged. None of 6 ovulation induction cycles resulted successful ovulation. Conclusion: Incidence of positive ovarian follicle in Korean premature ovarian failure patients is lower than that of Western counterpart. This result, however, could not be directly compared because of the differences of study design. The ovulation rate by medical ovulation induction in this group is 0%, which is worse than the reported success rate of Western studies.
키워드 : Premature ovarian failure, Ovulation, Koreans, Ovarian follicle, 조기난소부전, 배란, 한국인, 난포
교신저자 : pwi3110@eulji.ac.kr
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