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대한생식의학회지 제13권 제2호 2010년
비뇨기과 환자에서의 염색체 이상에 관한 연구
서울대학교 의과대학 비뇨기과학교실;서울대학교 의과대학 비뇨기과학교실;서울대학교 의과대학 산부인과학교실;서울대학교 의과대학 산부인과학교실;
김광명;최황;오선경;문신용;,
A Study of Chromosomal Abnormality in Urological Patients
Kim, Kwang-Myung;Choi, Hwang;Oh, Sun-Kyung;Moon, Shin-Yong;
Department of Urology, College of Medicine, Seoul National University;Department of Urology, College of Medicine, Seoul National University;Department of Obstetrics and Gynecology, College of Medicine, Seoul National University;Department of Obstetrics and Gynecology, College of Medicine, Seoul National University;
A chromosomal study was performed in a total of 162 urological patients during past 2$2{\frac{1}{2}}$ years (Feb. 1984 - Aug. 1986). Of these 78(48%) patients had abnormal chromosome complements. Among all patients with chromosome abnormalities, 88% (69/78) had aberrations of chromosome number, 8% (6/78) had aberrations of chromosome structure and 4% (3/78) had aberrations of both. 90% (65/72) of numerical abnormality was Klinefelter's syndrome and the structural abnormality rate (5.6%, 9/162) was less than that (6.99%) of general population. The chromosomal study was mandatory for the detection of intersex in small testes or hypospadias with cryptorchism or clitoromegaly or bilateral cryptorchism. But unilateral cryptochism or hypospadias with normal scrotal testes was not thought to be indication of the chromosomal study if the external genitalia are otherwise quite normal.
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