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대한생식의학회지 제13권 제2호 2010년
정계정맥류로 인한 불임증에 대한 췌장성 Kallikrein의 효능
서울대학교 의과대학 비뇨기과학교실, 서울대학교 인구의학연구소;서울대학교 의과대학 비뇨기과학교실, 서울대학교 인구의학연구소;서울대학교 의과대학 비뇨기과학교실, 서울대학교 인구의학연구소;서울대학교 의과대학 비뇨기과학교실, 서울대학교 인구의학연구소;
이희영;이상곤;김청수;이성원;,
Efficacy of Pancreatic Kallikrein on Semen Parameters of Men with Varicocele
Lee, Hee-Yong;Lee, Sang-Kon;Kim, Choung-Soo;Lee, Seung-Won;
Department of Urology, College of Medicine, Institute of Reproductive Medicine and Population, Seoul National University;Department of Urology, College of Medicine, Institute of Reproductive Medicine and Population, Seoul National University;Department of Urology, College of Medicine, Institute of Reproductive Medicine and Population, Seoul National University;Department of Urology, College of Medicine, Institute of Reproductive Medicine and Population, Seoul National University;
It has been reported that oral kallikrein therapy exerts a favourable effect on sperm motility in asthenozoospermic patients. In order to evaluate the efficacy of kallikrein on asthenozoospermia, a total of 20 subfertile male patients with varicocele, whose sperm counts were less than $40{\times}10^6/ml$ and sperm motility was less than 30%, was subjected to this clinical study (Table 1). They were divided into 2 study groups: 1) Varicocelectomy group consisted of 10 patients with varicocele (grade II-III) who underwent varicocelectomy. 2) Kallikrein group was composed of 10 patients with varicocele (grade I) who were given kallikrein orally 600 KU (kallikrein unit) daily divided 3 times after meal for 3 to 9 months. Semen analyses were repeated twice before the study, once a month during the study and twice after the study. Effective results designate that sperm parameters improved more than 30% from the basical levels after varicocelectomy or kallikrein exposure. Sperm counts increased from $32.5{\times}10^5/ml$ to $45.5{\times}10^6/ml$ after varicocelectomy in 3 patients and sperm motility increased from 25% to 38.5% after varicocelectomy in 3 patients. Pregnancy occurred in 2 patients of 3 responders and 1 patient of 7 non-responders 3 to 6 months after varicocelectomy in Varicocelectomy group. Sperm motility increased from 28% to 40.2% after kallikrein treatment in 3 patients. Pregnancy occurred in 2 patients of the 3 responders in Kallikrein group (Tables 2-3). There were no significant changes in volume and morphology in Varicocelectomy group before after varicocelectomy and no significant changes in volume, counts, and morphology before and after kallikrein exposure. No remarkable side effects were noted with kallikrein treatment.
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