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대한생식의학회지 제31권 제1호 2010년
한국여성에서 자궁내막증의 발생위험도와 Catechol-O- Methyltransferase 유전자 다형성과의 관련성에 관한 연구
이화여자대학교 의과대학 산부인과학교실, 건국대학교 산부인과학교실
이사라, 이소현,이운정,허성은,이지영,문혜성,정혜원
Association of the COMT Gene Polymorphism with the Risk of Endometriosis in Korean Women
Sa Ra Lee, So Hyun Lee, Woon Jeong Lee, Sung Eun Hur, Ji-Young Lee, Hye Sung Moon, Hye Won Chung
Department of Obstetrics and Gynecology, College of Medicine, Ewha woman's University, Department of Obstetrics and Gynecology, College of Medicine, Ewha woman's University
Objective : To investigate whether polymorphism of gene encoding COMT is associated with the risk of endometriosis in Korean women. Methods : We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant’s COMT genotype. Results : The distribution according to NIaIII genetic polymorphisms of COMT were as follows. COMT HH,COMT HL, and COMT LL genotypes were 56.6% (77 women), 34.6% (47 women) and 8.8% (12 women) in the study group and 50.6% (127 women), 39.4% (99 women) and 10.0% (25 women) in the control group. There was no significant difference between the study group and the control group. Conclusion : The results suggest that COMT genetic polymorphism may not be associated with the development of endometriosis in Korean women.
키워드 : Endometriosis, Genetic polymorphism, COMT, NIaIII
교신저자 : hyewon@mm.ewha.ac.kr
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