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대한생식의학회지 제31권 제3호 2010년
불임남성에서 Acetylcarnitine이 정액지표에 미치는 영향
성균관대학교 의과대학 비뇨기과교실1, 분당제생병원 비뇨기과2
김종우1, 이재석1,박정수2,김원태1,서주태1
Nonspecific Empirical Medical Therapy with Acetylcarnitine Effective in Oligoasthenospermic Men?
Jong Woo Kim1, Jae Seok Lee1, Jeong Su Park2, Won Tae Kim1, Ju Tae Seo1
1Department of Urology Sungkyunkwan University School of Medicine, Seoul, Korea, 2Department of Urology, Bundang Jesaeng Hospital, Seongnam, Korea
Purpose: To determine the efficacy of Carnitil￠c (acetylcarnitine, Hanmi, Korea) therapy in idiopathic oligoasthenospermic men. Materials and Methods: Forty-four subfertile men with abnormal semen parameters were treated between March, 2003 and March, 2004 with 3 g of Carnitil￠c daily for 3 months. Changes in semen parameters were evaluated 3 months after this therapy. Results: The mean age was 34.2 years and the mean follow-up duration was 3.7 months. In asthenospemic patients (n=28), semen analysis before and after Carnitil￠c treatment showed an increase in volume (2.64¡¾1.65 ml vs. 3.10¡¾1.60 ml), motility (35.1¡¾17.7% vs. 45.9¡¾20.4%) and viability (51.4¡¾20.3% vs. 59.3¡¾13.6%) respectively. In oligoasthenospermic patients (n=16), semen analysis before and after Carnitil￠c treatment showed an increase in sperm count (10.7¡¾54.4 million/ml vs. 38.4¡¾32.5 million/ml) respectively. Conclusions: These results suggested that in idiopathic oligoasthenospermic men the empirical medical therapy with acetylcarnitine may be considered as primary treatment
키워드 : Carnitine, Acetylcarnitine, Male infertility
교신저자 : jtand.seo@samsung.com
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