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대한생식의학회지 제32권 제1호 2010년
동결-융해 배아 이식에서 손상된 할구의 미세 수술적 제거의 임상적 효과
포천중문의과대학교 차병원 여성의학연구소
최원윤, 손지온, 박은아, 이동률, 이우식, 한세열, 박이석, 조정현, 김수희, 차광렬, 윤태기,
Clinical Outcomes of Frozen-thawed Embryo Transfer after Microsurgical Removal of Damaged Blastomere
Won Yun Choi, Jie Ohn Sohn, Eun A Park, Dong Ryul Lee, Woo Sik Lee, Se Yul Han, Lee Suk Park, Jung Hyun Cho, Soo Hee Kim, Kwang Yul Cha, Tae Ki Yoon
Fertility Center of CHA General Hospital, CHA ResearPochon CHA University, Seoul, Koreach Institute,
Objective: Human infertility clinics have been faced the demand for improving clinical results. The purpose of this study was to evaluate the effect of microsurgical removal of damaged blastomeres (DB) in frozen-thawed embryos on the clinical outcomes. Methods: From January 2003 to May 2004, out of 258 thawing ET cycles were divided into three groups: Group-1 (n=46): Intact cleavaged embryos after thawing. Remained cycles with embryos containing DB were randomly divided into two groups. Group-2 (n=102): Drilling zona pellucida (ZP) of frozen-thawed embryos by acidified Tyrode's solution. Group-3 (n=110): Drilling ZP and removal of DB. Embryos after microsurgical manipulation were transferred into the uterus of patients. Results: Clinical profiles and the mean number of transferred embryos among three groups were not different. Pregnancy and implantation rates were similar in three groups. It were 30.4% and 9.3% in Group-1, 29.4% and 7.8% in Group-2, and 26.4% and 7.6% in group-3, respectively. Miscarriage rate in Group-3 (37.9%) was slightly higher than those in Group-1 and Group-2 (14.3% and 23.3%), but it was not statistically significant. Conclusion: Intact cleaving embryos after DB removal showed higher potent of pregnancy and implantation. We could not find any improvement of clinical outcome by removal of DB in frozen-thawed embryos.
키워드 : Damaged blastomeres (DB), Microsurgical removed, Frozen-Thawed embryo, Pregnancy rate
교신저자 : journeyblue@hanmail.net
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