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대한생식의학회지 제32권 제2호 2010년
말초 혈액 CD56+Natural Killer Cell 증가에 기인한 습관성 유산 환자에서 정맥 내 면역글로블린 치료의 효과에 관한 연구
성균관대학교 의과대학 삼성제일병원 산부인과1, 진단검사의학과2
차선화1,, 박찬우1,김해숙1,조동희2,김진영1,강인수1,궁미경1,양광문1
Effectiveness of Intravenous Immunoglobulin Therapy in Women with Recurrent Spontaneous Abortions and Elevated Pre-conceptional Peripheral Blood CD56+ Natural Killer Cell Percentage
Sun Hwa Cha1, Chan Woo Park1, Hae Suk Kim1, Dong Hee Cho2, Jin Young Kim1, Inn Soo Kang1, Mi Kyoung Koong1, Kwang Moon Yang1
1Department of Ob/Gyn, 2Department of Laboratory Medicine, Samsung Cheil Hospital, SungKyunkwan University School of Medicine, Seoul, Korea
.
Objective: The aim of present study was to evaluate the effectiveness of low-dose intravenous immunoglobulin (IVIg) therapy in women with recurrent spontaneous abortions (RSA) and elevated pre-conceptional peripheral blood CD56+Natural Killer (NK) cell percentage. Study Design: Retrospective case control study. Materials and Methods: Thirty three women with RSA and elevated pre-conceptional peripheral blood CD56+NK cell percentage who had received low-dose IVIg therapy (400 mg/kg per day, every 4 week, until 20 gestational weeks) were included in this study. Controls were nine women with RSA and elevated pre-conceptional peripheral blood CD56+ Natural Killer (NK) cell percentage who had not received IVIg therapy were included in this study. Medical records of study and control groups were retrospectively analyzed and we compared the successful pregnancy outcomes between two groups. Successful pregnancy outcome was defined as pregnancy ongoing beyond 25 gestational weeks. Results: Age, number of previous abortions, pre-conceptional CD56+NK cell percentage and type of RSA were not statistically different between two groups. Otherwise, twenty-five women who received IVIg therapy (25/33, 75.8%) but, only three women who had not received (3/9, 33.3%) had a successful pregnancy outcome and the rate difference between two groups was statistically significant. Conclusion: Based on our study, low-dose IVIg therapy have a effective role in treatment of RSA patients with elevated pre-conceptional peripheral blood CD56+ Natural Killer (NK) cell percentage, but more larger scaled prospective study is needed for available of conclusive evidence.
키워드 : Natural Killer cells, Intravenous immunoglobulin, Recurrent spontaneous abortion
교신저자 : ykm2955@yahoo.co.kr
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