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대한생식의학회지 제35권 제1호 2010년
한국 불임 여성에서 난포자극호르몬 수용체 유전자형과 체외수정 및 배아이식술 임상 결과와의 관련성
관동대학교 의과대학 제일병원 생식생물학 및 불임연구실1, 산부인과학교실2
문미혜1, 최혜원1, 김민지1, 이형송1, 차선화2, 송인옥2, 궁미경2, 전진현1*,
Relationship between FSH Receptor Genotype and Clinical Outcomes of IVF-ET in Infertile Korean Women
Mi-Hye Moon1, Hye Won Choi1, Min Jee Kim1, Hyoung-Song Lee1, Sun Hwa Cha2, In Ok Song2, Mi Kyoung Koong2, Jin Hyun Jun1*
1Laboratory of Reproductive Biology & Infertility, 2Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea
Objective: The purposes of this study were to determine the distribution of follicle-stimulating hormone receptor (FSHR) genotypes in infertile Korean women and to evaluate the relationship between FSHR genotypes and clinical outcomes of IVF-ET cycles. Methods: Genomic DNA was extracted from peripheral blood in 1,020 of infertile Korean women. Genotypes of FSHR at Thr307Ala (T/A) and Asn680Ser (N/S) were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Clinical outcomes related to the genotypes of FSHR were evaluated in IVF-ET cycles (n=302) with controlled ovarian hyperstimulation (COH) of infertile women under 40 years old. Results: In a population of 1,020 infertile Korean women, the frequency of TT/NN, TA/NS and AA/SS for the major variant Thr307Ala and Asn680Ser was 44.80%, 41.96% and 10.49%, respectively. There was no significant difference in characteristics of ovarian response and clinical pregnancy rate among the major genotypes of FSHR in IVF-ET cycles with COH. However, implantation rate of AA/SS patients was significantly higher than that of TT/NN patients (24.5% vs 15.7%, p<0.05). Conclusion: This study showed that FSHR genotype was not directly associated with ovarian response in IVF-ET cycles with COH. The relationship between clinical outcomes and FSHR genotypes of patients should be substantiated by further studies.
키워드 : Follicle-stimulating hormone receptor (FSHR), Genotype, Controlled ovarian hyperstimulation (COH), Ovarian response, Clinical outcomes
교신저자 : junjh55@hanmail.net
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