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대한생식의학회지 제27권 제3호 2010년
인간의 정상 자궁내막조직에서의 BCL-2와 BAX 단백질의 발현
연세대학교 의과대학 산부인과학교실, 병리학교실1, 가천의과대학부속 길병원 산부인과학교실2, 포천 중문의과대학 산부인과학교실3
홍순옥, 이병석, 양우익1, 이지성2, 차동현, 조용선3, 김정연, 박기현, 조동제, 송찬호,
BCL-2 and BAX Expression in Normal Human Endometrium
Soon Oak Hong, Byung Seok Lee, Woo Ick Yang1, Jee Sung Lee2, Dong Hyun Cha, Yong Seon Cho3, Jeong Yeon Kim, Ki Hyun Park, Dong Jae Cho, Chan Ho Song
Department of Obstetrics and Gynecology, Department of Pathology1, College of Medicine, Yonsei University, Seoul, Department of Obstetrics and Gynecology, Gachon Medical College, Gil Medical Center2, Incheon, Department of Obstetrics and Gynecology, College of Medicine, Pochun CHA university3, Seoul, Korea
Objective: To investigate the distribution of BCL-2, BAX proteins and DNA fragmented cells in the normal human endometrium during at each menstrual cycle in order to find out whether apoptosis regulates cyclic endometrial change. Methods: Normal endometrial tissues were Obtained from 40 patients, 32~45 year of age, all with regular menstrual cycle, who were undergoing abdominal hysterectomy for myoma of uterus or cervical intraepithelial neoplasia for the period from 1992 through 1997. Immunohistochemical staining was used to determine the expression of BCL-2 and BAX protein paraffin-embedded tissues. Results: BCL-2 was expressed on the glandular epithelial cells and stromal cells during the proliferative phase. The intensity of BCL-2 was increased predominantly on the basal layer than the functional layer in late proliferative phase. However, BCL-2 immunoreactivity was decreased in the secretory phase. BAX was expressed predominantly during the secretory phase. The intesity was increased in late secretory phase rather than early secretory phase. DNA fragmented cells were detected in a few cells at each phase. However, it was increased during the late secretory phase. Conclusion: Apoptosis-related genes, BCL-2 and BAX, may play a role in the regulation of cyclic endometrial change.
키워드 : Endometrium, BCL-2, BAX, Apoptosis
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