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대한생식의학회지 제35권 제2호 2010년
말초혈액자연살해세포가 증가된 반복유산 환자의 탈락막자연살해세포의 발현
린산부인과1, 관동대학교 의과대학 제일병원 산부인과학교실2, 진단병리과3, 임상병리과4, 인제대학교 의과대학 상계백병원 산부인과학교실5
연명진1, 양광문2*, 박찬우2, 송인옥2, 강인수2, 홍성란3, 조동희4, 조용균5,
Expression of Decidual Natural Killer (NK) Cells in Women of Recurrent Abortion with Increased Peripheral NK Cells
Myeong Jin Yeon1, Kwang Moon Yang2*, Chan Woo Park2, In Ok Song2, Inn Soo Kang2, Sung Ran Hong3, Dong Hee Cho4, Yong Kyoon Cho5
1Lin Women's Hospital, 2Department of Obstetrics and Gynecology,3Department of Pathology, 4Department of Clinical Pathology, Cheil General Hospital & Women's Healthcare Center, Kwandong University, College of Medicine, Seoul, Korea, 5Department of Obstetrics and Gynecology, Inje University, Sanggye Paik Hospital, Seoul, Korea
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Objective: The purpose of this study was to quantify decidual CD56+ and CD16+ NK cell subtype population and to evaluate the correlation between decidual NK cell expression and peripheral CD56+ NK cell expression in women with a history of recurrent abortion and increased peripheral NK cells. Methods: Twenty-nine women with recurrent abortion and elevated peripheral CD56+ NK cell percentage who had chromosomally normal conceptus were included in this study. Thirty-two women with recurrent abortion who had chromosomally abnormal conceptus were used as controls. Distribution of CD56+ and CD16+ NK cells in decidual tissues including implantation sites was examined by immunohistochemical staining. The degree of immunohistochemical staining was interpreted by score and percentage. Results: There was a significant difference in decidual CD56+ NK cell score (43.6¡¾24.5 vs. 23.9¡¾16.3 P =0.001) and CD56+ NK cell percentage (42.1¡¾11.7 vs. 33.9¡¾15.8 P =0.027) between increased peripheral NK cell group and control group. However, there was no statistically significant difference in decidual CD16+ NK cell score (18.7¡¾9.5 vs. 13.2¡¾39.4 P =0.108) and CD16+ NK cell percentage (24.7¡¾5.9 vs. 23.4¡¾11.7 P =0.599). There was no significant correlation between decidual NK cell score and peripheral NK cell percentage in increase peripheral NK cell group (peripheral CD56+ NK cell percentage vs. decidual CD56+ NK cell score, r=-0.016, P =0.932, peripheral CD16+ NK cell percentage vs. decidual CD16+ NK cell score, r=0.008, P =0.968). Conclusion: This study shows that CD56+ decidual NK cells are increased in decidua of women exhibiting a history of recurrent abortion with increased CD56+ peripheral NK cell. There was no significant correlation between decidual and peripheral NK cell increment in increase peripheral NK cell group. This study suggests the possibility that decidual NK cells may play an important role in the immune mechanism of recurrent abortion.
키워드 : Decidual natural killer cell, CD56+/CD16+ NK cell, Recurrent abortion
교신저자 : ykm2955@yahoo.co.kr
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