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대한생식의학회지 제35권 제3호 2010년
체외수정 및 배아이식술에서 레이저를 이용한 보조부화술의 효용성에 대한 연구
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윤태기, 이정현, 한지은, 김유신, 원형재, 조정현, 곽인평, 엄진희
Efficacy of Assisted Hatching by Laser in Human IVF-ET Program
Tae Ki Yoon
Fertility Center of CHA General Hospital, CHA Research Institute, Pochon CHA University
Objective: To evaluate efficacy of assisted hatching by laser (AHL) and acidified Tyrode solution (AHA) in selected groups of IVF-ET patients who have a poor prognosis. Methods: From February 2006 to September 2006, total of 328 IVF-ET cycles with advanced female age (≥38 years), recurrent implantation failure (≥3 cycles), thick zona (≥17 μm), and/or poor quality of embryo were randomly divided into assisted hatching by acidified Tyrode solution (AHA, n=180) and the assisted hatching using the ZILOS-tk laser (AHL, n=148) groups. Clinical outcomes were analyzed and compared between AHA and AHL group based on the patient characteristics. Results: In all AHL and AHA group, there were no significant differences in pregnancy (42.6%, 63/148 vs. 33.3%, 60/180) and implantation rates (17.4%, 82/470 vs. 16.0%, 89/556) However, in advanced female age group (Group 1), pregnancy (37.0%, 20/54 vs. 18.7%, 14/75) and implantation rates (14.4%, 23/160 vs. 7.1%, 15/210) in AHL group were significantly (p<0.05) higher than those of AHA, although there was no difference in patient parameters of both groups. And, the clinical outcome of groups with recurrent implantation failure (Group 2), thick zona pellucida (Group 3) and poor quality embryo (Group 4) were improved in AHL compared to those of AHA: 43.8% (21/48) and 31.6% (25/79) in Group 2, 43.8% (32/73) and 34.1% (28/82) in Group 3, 25.0% (7/28) and 14.6% (6/41) in Group 4, but no significance. Conclusion: The AHL improved the pregnancy and implantation rates in patients with advanced female age and recurrent implantation failure when compared to outcomes achieved from AHA. Therefore, this AHL technique may be a efficient and safe method for patients with poor prognosis.
키워드 : Assisted hatching, Laser, Acidified Tyroid's solution, IVF-ET, Clinical outcome, 보조부화술, 레이저, Acidified Tyroid's solution, 체외수정 시술, 임상결과
교신저자 : tkyoon@cha.ac.kr
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