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대한생식의학회지 제3권 제1호 2010년

정상(正常) 임산부(妊産婦)의 혈청중(血淸中) H.P.L.의 면역학적(免疫學的) 측정(測定)에 관(關)한 연구(硏究)

서울대학교 의과대학 산부인과학교실;서울대학교 의과대학 산부인과학교실;

정애리;신면우;,

H.P.L. Value in Serum of Normal Pregnancy and Pospartum State by Hemagglutination-Inhibition Reaction

Chung, Ae-Rhee;Shin, Myun-Woo;

Department of Obstetrics and Gynecology, S.N.U.H.;Department of Obstetrics and Gynecology, S.N.U.H.;

Serum levels of human placental lactogen have been measured by hemagglutination-inhibition reaction in 67 normal pregnant state and in 15 postpartum 24 hour state, HAIR is less sensitive and reliable method than radioimmunoassay, but simple, rapid, less expensive and fairly accurate, so it is more helpful in screening of large antenatal population with or without high risk complications. 1) Sensitivity of HPL-HAIR test kit was $0.1{\mu}g$/ml of H.P.L. serum level and had no cross reaction to HCG or male serum or non-pregenant female or newborn infant, 2) H.P.L. value was around $2{\mu}g$/ml until 24th week of pregnancy and rose to $6{\sim}8$ ${\mu}g$/ml continuously until about 36th week of pregnancy and then slightly decreased or stationary. 3) H.P.L. value in postpartum 24 hour state was undetectable. 4) There was poor correlation between maternal serum H.P.L. value at term and baby weight.

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