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대한생식의학회지 제14권 제2호 2010년
세포분열이 왕성한 생쥐 배세포에서 세포분열에 대한
성신여자대학교 자연과학대학 생물학과;서울대학교 대학원 동물학과;
배인하;박지혜;,
Studies on the Requirements of
Bae, In-Ha;Park, Ji-Hye;
Department. of Biology., College of Natural Science, Sungshin Women's University;Department. of Zoology., Graduate School, Seoul National University;
To determine the effect of calcium on the preimplantational development of mouse two-cell embryo, the various concentrations of calcium were added into the culture media and the rate of blastocyst formation was observed. Also, to examine the effect of trifluoperazine, an inhibitor of calmodulin which is involved in the several intracellular calcium functions, embryos were cultured for 48 hours at the various concentrations of this inhibitor. An additional 24 hour culture was done to examine the effect of this drug on the transformation from morula to blastocyst. The results are as following ; 1. About 1.71mM of extracellular calcium is adequate for blastocyst formation and the higher concentrations of calcium (3.43mM and 8.55mM) do not affect on the blastocyst formation and the degenerating rate. 2. Trifluoperazine
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