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대한생식의학회지 제18권 제1호 2010년

인간의 체외수정과 투명대제거 햄스터난자의 침투능에 관한 연구

경희대학교 의과대학 산부인과학교실 (불임크리??);경희대학교 의과대학 산부인과학교실 (불임크리??);경희대학교 의과대학 산부인과학교실 (불임크리??);건국대학교 축산대학 축산학과;

김재명;서병희;이재현;정길생;,

Correlation for Human in Vitro Fertilization with the Zona-Free Hamster Penetration Assay

Kim, Jae-Myeoung;Suh, Byung-Hee;Lee, Jae-Hyun;Chung, Kil-Sheng;

Infertility Clinic Department of Obstetrics and Gynecology, Kyung Hee University, College of Medicine;Infertility Clinic Department of Obstetrics and Gynecology, Kyung Hee University, College of Medicine;Infertility Clinic Department of Obstetrics and Gynecology, Kyung Hee University, College of Medicine;Department of Animal Husbandary, Kon-Kuk University;

We compared fertilizing potential measurements by the zona-free hamster egg penetration assay with the in vitro fertilization and embryo transfer program was evaevulated for their ability to fertilize zona free hamster egg. Spermatozoa from 12 presumeably fertile donors and from the male partners of 56 infertile couples were evaluated for their ability to fertilizing potentials. Penertration rates of fertile donors were $36.2{\pm}27.7%$ ; Fertilization rates of infertile couples between with normal semen parameters and with abnormal semen parameters were $28.7{\pm}19.1$, $5.7{\pm}8.9%$, respectively. Sperm motility of couples with penetration rates between on 15-30% and on 30> were $54.1{\pm}4.6$, $55.5{\pm}8.3%$ respectively. Hamster penetration rates of couples participating in an in vitro fertilization and embryo transfer program was $38.9{\pm}29.9%$. But in one case, a positive fertility assessment was obtained in the absence of fertilization of the wife's eggs attributable to egg immaturity. This method may have potential value as a diagnostic tool in evaluation human sperm fertilization capacity which avoids the ethical and logistical problems associated with fertilizing of human eggs in vitro.

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