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대한생식의학회지 제18권 제2호 2010년
Platelet-Activating Factor (PAF)가 생쥐의 배란, 초기배아의 발달 및 착상에 미치는 영향
충남대학교 의과대학 산부인과학교실;충남대학교 의과대학 산부인과학교실;
강길전;이영일;,
Effect of Platelet-Activating Factor (PAF) on Murine Ovulation, Early Embryo Development and Implantation
Kang, Kil-Chun;Lee, Young-Il;
Department of Obstetrics and Gynecology, College of Medicine, Chungnam National University;Department of Obstetrics and Gynecology, College of Medicine, Chungnam National University;
An embryo-derived platelet activating factor (PAF) has been demonstrated to play an important role in reproduction. This report examined the effect of PAF on ovulation, fertilization, embryo development, implantation and fetal viability by using murine model. PAF had no stimulatory effect on ovulation and fertilization. But PAF had stimulatory effect on embryo development in in-vitro test, in spite of no effect on implantation and fetal viability. These results demonstrate that exogenous PAF could enhance embryo development and implantation and give suggestion that PAF may play an role in human IVF program.
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