| 학회지 검색 | HOME > 논문 및 학회지 > 학회지 검색 |
대한생식의학회지 제18권 제2호 2010년
자궁근종시 LHRH agonist (D-Trp6-LHRH) 치료에 따른 근종세포내 미세구조의 변화
연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;
박기현;신명철;이보연;이병석;송찬호;,
Electron Microscopic Ultrastructural Changes of Leiomyoma after Treatment with D-Trp6-Luteinizing Hormone Releasing Hormone
Park, K.H.;Shin, M.C.;Lee, B.Y.;Lee, B.S.;Song, C.H.;
Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;Department of Obstetrics and Gynecology, Yonsei University, College of Medicine;
Long-term administration of luteinizing hormone-releasing hormone(LHRH) agonists, through a process of pituitary desensitization and down-regulation of receptors, inhibits the secretion of gonadotropin and sex-steroids and induces a reversible suppression of gonadal activity. This approach can be used as an effective endocrine therapy for some hormone-dependent tumors. We have used D-Trp6-LHRH, a long acting LHRH agonist, for the treatment of eleven patients with uterine leiomyomas, thereafter myomectomy was performed in seven cases and observed the ultrastructural changes of leiomyoma with an electron microscope. The use of LHRH agonist may be effective in reducing the size of a myoma considerably by primarily inducing medical hypophysectomy and would allow easier surgical removal. Electron microscopic findings of myoma cells after the use of LHRH agonist included the following: loss of cristae and swelling nuclear chromatin, perinuclear vacuolation in cytoplasm. Bone mineral density was slightly decreased, however, the difference was not statistically significant.
키워드 :
교신저자 :
전문 파일 : 
