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대한생식의학회지 제18권 제2호 2010년
반복유산을 경험한 384부부의 세포유전학적 연구
제일병원 유전학연구실;제일병원 산부인과;영동제일의원;한양대학교 의과대학;한양대학교 의과대학;
최수경;민응기;노성일;백용균;유명수;,
Cytogenetic Studies of 384 Couples with Recurrent Abortion
Choi, Soo-Kyung;Min, Eung-Ki;Roh, Sung-Il;Paik, Yong-Kyun;Lyu, Myung-Soo;
Genetics Research Laboratory, Jeil General Hospital;Department of Obstetrics and Gynecology, Jeil General Hospital;Yong Dong Jeil Clinic;Department of genetics, Hanyang University, School of Medicine;Department of genetics, Hanyang University, School of Medicine;
During the years 1984 to 1989, in order to determine of chromosome abnormalities are associated with recurrent spontaneous abortions, cytogenetic studies were performed 384 couples. Abnormal karyotypes were found in 51(13.3%) couples. There was no apparent relation with the number of abortions. The abnormalities were as follows: 17(4.4%) balanced translocation; 15(3.9%) mosaicisms; 17(4.4%) pericentric inversion; 2(0.5%) addition or isochromosome. Chromosome abnormalities were observed in 34(67%) of the wives and 17(33%) of the husbands. In addition, we detected polymorphic variants of chromosomes in 89(23.2%) subjects. Reciprocal translocations(13/17) were more common than the robertsonian type(4/17). All of the mosaicisms were associated with the sex chromosomes in 10 females and 5 males subjects. Pericentric inversions were most common in chromosome 9. Compared to previously studied general populations, significantly higher frequencies of translocations, mosaicisms and inversions were found in couples with repetitive spontaneous abortion. This suggests that couples should have chromosome studies after two or more abortions.
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