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대한생식의학회지 제21권 제3호 2010년
체외수정 및 배아이식술에서 세포질내 정자주입술(ICSI)의 수정률과 임신율
제일병원 체외수정연구실;제일병원 체외수정연구실;제일병원 체외수정연구실;제일병원 비뇨기과;제일병원 비뇨기과;제일병원 비뇨기과;제일병원 산부인과 불임크리닉;제일병원 산부인과 불임크리닉;
전진현;이호준;김정욱;박용석;이유식;홍재엽;손일표;전종영;,
Fertilization and Pregnancy Rate of Intracytoplasmic Sperm Injection(ICSI)
Jun, Jin-Hyun;Lee, Ho-Joon;Kim, Jeong-Wook;Park, Yong-Seog;Lee, Yu-Sik;Hong, Jae-Yup;Son, Il-Pyo;Jun, Jong-Young;
Cheil General Hospital Infertility Clinic;Cheil General Hospital Infertility Clinic;Cheil General Hospital Infertility Clinic;Cheil General Hospital Infertility Clinic;Cheil General Hospital Infertility Clinic;Cheil General Hospital Infertility Clinic;Cheil General Hospital Infertility Clinic;Cheil General Hospital Infertility Clinic;
Intracytoplasmic sperm injection(ICSI) was known as effective method in treatments of couples who unable to be helped by conventional in vitro fertilization. In 78 treatment cycles of 78 infertile couples using ICSI performed at our infertility clinic between May and August 1994 were analyzed. These patients were classified two groups, andrological factor(AF) and non-andrological factor(non-AF) group. The AF group, which had abnormal sperm physiology, included oligozoospermia, asthenozoospermia, oligoasthenoteratozoospermia(OATS) and microsurgical epididymal sperm aspiration(MESA) patients. The non-AF group, which had abnormal oocyte physiology, included abnormal zona pellucida, poor quality of oocyte and immune factor infertile patients. A single spermatozoon was injected into the ooplasm of 776 metaphase II oocytes. The fertilization rate was 44.6%(346/776) and 319 embryos were transferred. After 73 embryo transfers(93.6% of treatment cycles) 23 pregnancies were estabilshed, i. e. pregnancy rate of 29.4% per started cycle and 31.5% per embryo transfer. Fertilization rate of AF and non-AF group was 46.2% and 35.8%, pregnancy rate was 34.5%(20/58) and 20.0%(3/15), respectively. In order to increase the pregnancy rate, assisted hatching(AHA) has done after lCSl in 47 treatment cycles. Pregnancy rate of ICSI with AHA and without AHA group was 34. 0% (16/47) and 26.9%(7/26), respectively. ICSI was more effective in andrological factor infertility and the pregnancy rate was increased by ICSI with AHA procedure.
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