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대한생식의학회지 제21권 제3호 2010년
방사선 처리를 받은 흰쥐의 혈청내 스테로이드호르몬의 변화
한양대학교 자연과학대학 생물학교실;한양대학교 자연과학대학 생물학교실;한양대학교 자연과학대학 생물학교실;한양대학교 자연과학대학 생물학교실;
신장식;이영근;김문규;윤용달;,
Change of Serum Steroid Level in the Whole-body Irradiated Rat
Shin, Jang-Sik;Lee, Young-Keun;Kim, Moon-Kyoo;Yoon, Yong-Dal;
Department of Biology, College of Natural Sciences, Hanyang University;Department of Biology, College of Natural Sciences, Hanyang University;Department of Biology, College of Natural Sciences, Hanyang University;Department of Biology, College of Natural Sciences, Hanyang University;
The effect of radiation on the steroidogenesis of rat ovary was investigated. For this purpose, female rats aged 7-8 weeks were exposed to a single dose of ${\gamma}$ radiation(320 rad or 800 rad) by the cobalt-60. At fourth(day of the first estrus) and eighth(day of the second estrus) days after irradiation, the concentrations of serum steroid hormones were determined by radioimmunoassays (RIA). The correlation between survival rate(Y) and radiation dose(X) was Y=-0.06X+100(r=0.89, n=10). Lethal dose$(LD)_{50(30)}$ and $LD_{20(30)}$ were 833.33rad and 333.33rad respectively. The weights of body and ovary was decreased significantly by the $LD_{50(30)}$ irradiation during the 4 days, but both weights were recovered at day 8. The serum levels of 17a-hydroxyprogesterone(170HP) and estradiol($E_2$) in the irradiated rats were not generally different from those of control. However, the levels of testosterone(T) and 19-norterstosterone(19NT) in the irradiated rat at $LD_{50(30)}$ and $LD_{20(30)}$ radiation doses were decreased, while progesterone levels in serum of the irradiated rats were slightly increased. These results suggest that irradiation may inhibit the first step of steroidogenesis, especially the conversion of P to T, in the rat ovary.
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