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대한생식의학회지 제24권 제3호 2010년

정자 직접 주입법 (ICSI) 이후에 수정에 실패한 인간 난자에 대한 염색체 분석

포천중문의과대학교 차병원 여성의학연구소;포천중문의과대학교 차병원 여성의학연구소;포천중문의과대학교 차병원 여성의학연구소;포천중문의과대학교 차병원 여성의학연구소;포천중문의과대학교 차병원 여성의학연구소;포천중문의과대학교 차병원 여성의학연구소;포천중문의과대학교 차병원 여성의학연구소;

손원영;박성은;정형민;엄기붕;고정재;윤태기;차광열;,

Chromosomal Analysis of the Human Oocytes Failed to Fertilize following Intracytoplasmic Sperm Injection (ICSI)

Son, W.Y.;Park, S.E.;Chung, H.M.;Oum, K.B.;Ko, J.J.;Yoon, T.K.;Cha, K.Y.;

Infertility Medical Center, CHA General Hospital, College of Medicine, Pochon CHA University;Infertility Medical Center, CHA General Hospital, College of Medicine, Pochon CHA University;Infertility Medical Center, CHA General Hospital, College of Medicine, Pochon CHA University;Infertility Medical Center, CHA General Hospital, College of Medicine, Pochon CHA University;Infertility Medical Center, CHA General Hospital, College of Medicine, Pochon CHA University;Infertility Medical Center, CHA General Hospital, College of Medicine, Pochon CHA University;Infertility Medical Center, CHA General Hospital, College of Medicine, Pochon CHA University;

Despite the direct placement of sperm within the oocyte, fertilization failure still occurs after ICSI. This study was accomplished to analyze the chromosomes in oocytes failed to fertilize after ICSI comparing to oocytes failed to fertilize by conventional in vitro insemination. Seventy-four ICSI cycles and 122 conventional IVF cycles were included in analysis. Included unfertilized oocytes were from 74 patients (mean age = $32.7{\pm}3.7$). Ninety-three oocytes were informative and 83 oocytes were legible for cytogenetic analysis. Sixty-two oocytes out of 83 (74.7%) had normal chroruosomes, while 15 (18.1%) were hypoploidy, 6 (7.2%) were hyperploidy. Eighteen oocytes out of 93 (17.6%) were premature chromosome condensation (PCC). Two hundred ninety-four unfertilized oocytes after conventional insemination were subjected to chromosomal analysis and 180 oocytes were legible for analysis. One hundred thirty-two oocytes out of 180 (73.3%) were normal, while 22 (12.2%) were hypoploidy, 20 (11.1%) were hyperploidy, and 6 (3.3%) were polyploidy. Twenty-two oocytes (12.2%) were PCC. There was no difference in chromosomes between oocytes that failed to fertilize after ICSI or conventional insemination. High PCC rates in fertilization-failed oocytes suggest that oocytes maturity is another important factor in achieving successful fertilization.

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