:: 대한생식의학회 ::

논문 및 학회지

학회지 검색

HOME > 논문 및 학회지 > 학회지 검색

대한생식의학회지 제24권 제3호 2010년

자궁근종과 자궁평활근 세포분열에 있어 Interferon-${\alpha}$ 및 basic Fibroblast Growth Factor (bFGF)의 효과

연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;연세대학교 의과대학 산부인과학교실;

이병석;박정식;김진영;배상욱;박기현;조동제;이국;김재욱;송찬호;,

The Effect of Interferon-${\alpha}$ and bFGF on the Proliferation of Cultured Leiomyoma and Myometrial Cells

Lee, B.S.;Park, J.S.;Kim, J.Y.;Bae, S.W.;Park, K.H.;Cho, D.J.;Lee, K.d;Kim, J.W.;Song, C.H.;

Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;Department of Obstetrics and Gynecology, College of Medicine, Yonsei University;

Leiomyomas, which are the commonest pelvic tumors in women, are originated from myometrial cells. Although the exact initial pathophysiologic event of the leiomyoma is not known, recent evidences suggested that the effects of sex steroid hormones in the process of tumor growth are mediated by local production of growth factors including epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II). If we look at the effects of other cytokines, it was suggested that basic fibroblast growth factor (bFGF) may stimulate the proliferation of myometrial and leiomyomas cells. And it was reported that interferon-${\alpha}$ inhibit the action of bFGF. Therefore, we examined the effect of bFGF and interferon-${\alpha}$ on the proliferation of leiomyoma and myometrial cells. bFGF stimulated the myometrial and leiomyoma cells significantly at the concentration of 1ng/ml (p<0.05) and 5ng/ml (p<0.05). However, Interferon-${\alpha}$ inhibited the cell proliferation of myometrial and leiomyoma cells significantly at the concentration of 100U/ml (p<0.05) and 1000U/ml (p<0.05). And the stimulated effects of bFGF with the various concentration on the myometrial and leiomyoma cells ware inhibited by interferon-${\alpha}$ with 100U/ml. Therefore, we concluded that bFGF may stimulate the myometrial and leiomyoma cell proliferation and interferon-${\alpha}$ may inhibit the myometrial and leiomyoma cell proliferation through blocking the effect of basic fibroblast growth factor.

키워드 :

교신저자 :
전문 파일 :