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대한생식의학회지   제27권 제2호 2010년

한국인 조기 난소부전 불임환자에서 황체형성 호르몬 유전자 변이 분석

포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실, 차병원 여성의학 연구소;포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실;분당 차병원 산부인과 및 불임센타;포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실, 차병원 여성의학 연구소;차병원 여성의학 연구소;분당 차병원 산부인과 및 불임센타;구미 차병원 산부인과;차병원 여성의학 연구소;포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실, 차병원 여성의학 연구소;포천중문 의과대학교 생화학교실 및 기초의학연구소 중앙연구실, 차병원 여성의학 연구소;

김남근;이유진;남윤성;이숙환;전혜선;박찬;김종욱;이경아;고정재;차광열;,

The Analysis of $LH{\beta}$-subunit Variants in Infertile Patients with Premature Ovarian Failure (POF) in Korea

Kim, Nam-Keun;Lee, Eu-Gene;Nam, Yoon-Sung;Lee, Sook-Hwan;Jeon, Hye-Sun;Park, Chan;Kim, Jong-Wook;Lee, Kyung-Ah;Ko, Jung-Jae;Cha, Kwang-Yul;

Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University, Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital;Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University;Obstetrics & Gynecology and Infertility Medical Center, Pundang CHA General Hospital;Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University, Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital;Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital;Obstetrics & Gynecology and Infertility Medical Center, Pundang CHA General Hospital;Department of Obstertics and Gynecology, Kumi CHA General Hospital;Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital;Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University, Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital;Department of Biochemistry and Central Laboratories, Institute of Medical Research, College of Medicine, Pochon CHA University, Infertility Medical Center and Obstetrics & Gynecology, CHA General Hospital;

This study was performed to determine whether the $LH{\beta}$-subunit gene missense mutation is present in Korean infertile patients with 46,XX POF women. The variants of $LH{\beta}$ exon 2 (Trp 8Arg; TGG to CGG and Ile15Thr; ATC to ACC) were studied in forty-four 46,XX idiopathic POF and 54 nonpregnant women. The $LH{\beta}$ exon 2 variants were more frequent in POF patients (20.5%) than nonpregnant (16.7%) women (p>0.05). POF patients with the variant was slightly higher than nonpregnant women with the variant.

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