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대한생식의학회지 제27권 제3호 2010년
시험관 아기 시술에서 여성의 연령이 수정란의 질과 다태 임신 발생에 미치는 영향
을지대학부속병원, 불임연구실;을지대학부속병원, 불임연구실;을지대학부속병원, 산부인과;을지대학부속병원, 산부인과;을지병원 의과학연구소;을지병원 의과학연구소;을지병원 의과학연구소;
이명섭;박장옥;정지학;박준숙;강희규;김동훈;이호준;,
Influence of Maternal Age on Embryo Quality and the Frequency of Multiple Pregnancy in IVF-ET Program
Lee, Myeong-Seop;Park, Jang-Ok;Jung, Ji-Hak;Park, Jun-Suk;Kang, Hee-Gyoo;Kim, Dong-Hoon;Lee, Ho-Joon;
Laboratory of Infertility Eulji University Hospital;Laboratory of Infertility Eulji University Hospital;Department of OB/GY, Eulji University Hospital;Department of OB/GY, Eulji University Hospital;Medical Science Institute, Eulji Medical Center;Medical Science Institute, Eulji Medical Center;Medical Science Institute, Eulji Medical Center;
Objective: This study was performed to evaluate the influence of maternal age on embryo quality and the frequency of multiple pregnancy in IVF-ET program. Method: 86 conventional IVF-ET cycles were divided into three groups according to the age by 5 year (group A: 26-30, group B: 31-35, group C: 36-40 yrs). The in vitro fertilization and development outcome (fertilization, cleavage and high quality embryo rate) and the pregnancy outcome (pregnancy, implantation, G-sac/high quality embryo and multiple pregnancy rate) were examined. And then, these results were compared among the groups. Results: The rates of fertilization (62.7, 68.5 and 65.4%, respectively) and cleavage (95.6, 97.6 and 98.0%, respectively) were not different among the groups. And the high quality embryo (HQE) rate also was not different among the groups (61.8, 62.9 and 62.8%, respectively). The pregnancy rate of group C (23.3%) was significantly lower than that of group A (41.2%) and B (48.7%). And the implantation rate was significantly decreased with advance in maternal age (group A; 17.3%, B; 12.6% and C; 6.0%). The G-sac/high quality embryo rate was significantly higher in group A (70.8%) when compared to group B (32.2%) and C (40.0%). On the other hand, the multiple pregnancy rate was significantly lower in group C (14.3%) when compared to group A (71.4%) and B (36.8%). Conclusion: The pregnancy rate was significantly decreased over 35 years. The G-sac/HQE and multiple pregnancy rate were significantly high below 31 years. Thus, these results suggest that the number of high quality embryo transferred should be limited by the age and another criteria for embryo quality evaluation were required for single embryo transfer.
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