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대한생식의학회지 제36권 제1호 2010년
폐쇄성 무정자증 환자와 정자형성저하증 환자의 고환정자를 이용한 체외수정 및 배아이식술의 결과
관동대학교 의과대학 제일병원 생식생물학 및 불임연구실1, 산부인과2, 비뇨기과3
한상철1, 박용석1*, 최수진1, 이선희1, 홍승범1, 이형송1, 임천규1, 송인옥2, 서주태3,
Clinical Outcome of IVF-ET using Testicular Sperm Retrieved from Patients with Obstructive Azoospermia or Hypospermatogenesis
Sang Chul Han1, Yong-Seog Park1*, Su Jin Choi1, Sun-Hee Lee1, Seung Bum Hong1, Hyoung Song Lee1, Chun Kyu Lim1, In Ok Song2, Ju Tae Seo3
1Laboratory of Reproductive Biology and Infertility, 2Department of Obsterics and Gynecology,3Department of Urology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea
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Objective: To compare the clinical outcomes of ICSI with sperm retrieved from testicular tissue in patients with obstructive azoospermia (OA) or hypospermatogenesis (HS). Methods: From January 2003 through December 2006, 155 patients with OA (241 cycles) and 28 patients with HS (34 cycles) were included in this study. We compared clinical outcomes of ICSI with testicular sperm such as fertilization rate, implantation rate, clinical pregnancy rate and delivery rate. Data were statistically analyzed using t-test and χ2-test. Results: Testicular spermatozoa could not be retrieved in 1 out of the 21 cycles where fresh testicular sperm extraction in HS patients. Fertilization rate (FR) was significantly higher in OA than HS (75.6 % vs. 62.6%, p<0.001). Cleavage rate (CR) per fertilized zygote was also significantly higher in OA than that in HS (66.8% vs. 54.8% p<0.001). However, there were no significant differences in good embryo rate (GER), clinical pregnancy rate (CPR), implantation rate (IR) and delivery rate (DR). Conclusion: Our results show that testicular sperm of HS does not affect CPR, IR, and DR although it has shown reduced FR and CR.
키워드 : Obstructive azoospermia, Hypospermatogenesis, Testicular spermatozoa, ICSI
교신저자 : arkangel@daum.net
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