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대한생식의학회지 제26권 제3호 2010년
무월경 환자의 세포유전학적인 연구
서울대학교 의과대학 산부인과학 교실1 ,의학 연구원 인구의학 연구소2, 이화여자대학교 의과대학 산부인과학 교실
이경순, 한정호, 문신용,
A Cytogenetic Study of Amenorrhea
Lee ks, Han jh, Moon sy
Objectives ; Cytogenetic investigations were carried out on 770 women with primary(n=560) and secondary amenorrhea(n=210) to determine the frequency of chromosomal or genetic causes of amenorrhea. Materials and Methods ; In 770 women with parimary amenorrhea(n=560) and secondary amenorrhea (n=210), chromosomal analysis were performed. Results 1) The most prevalent age group is 16-20 years of age group with primary amenorrhea and 26-30 years of age group with secondary amenorrhea. 2) Out of 560 cases of primary amenorrhea, 343 cases(61.3%) had the normal chromosome constitution and 217 cases(38.7%) had the abnormal chromosome constitution including 46,XY. 3) In 217 cases of abnormal chromosome of primary amenorrhea, 57 cases( 26.3 %) had 45,X and 34 cases(15.8%) had the 46,XY, 24 cases(11.0%) had 45,X/46,X,i(Xq), 23 cases (10.6%) had 45,X/46,X,+mar and 14 cases(6.6%) had 45,X/46,XY. 4) Out of 210 cases of secondary amenorrhea, 181 cases(86.2%) had the normal chromosome constitution and 29 cases(13.8%) had the abnormal chromosome. 5) In 29 cases of abnormal chromosome of secondary amenorrhea, 7 cases (24.1%) had 45,X/46,X,i(Xq), 4 cases(13.8%) had 45,X/46,XX. Conclusion ; High percentage of chromosomal abnormalities was diagnosed in primary amenorrhea and most of them were sex chromosome anomalies. In secondary amenorrhea, the prevalence was lower than primary amenorrhea, so a preselection of patients with secondary amenorrhea for cytogenetic investigations seems to be necessary.
키워드 : Amenorrhea, Cytogenetic study, Chromosome, Karyotype
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