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대한생식의학회지 제26권 제3호 2010년
습관성 유산 환자의 세포유전학적인 연구
이화여자대학교 의과대학 산부인과학 교실1, 서울대학교 의과대학 산부인과학 교실2, 서울대학교 의학연구원 인구의학연구소3
이경순1, 한정호3, 오선경3, 문신용23,
A Cytogenetic Study of Recurrent Spontaneous Abortion
Lee ks, Han jh, Oh sk, Moon sy
Objective: The purpose of this investigation is to determine the frequency of chromosomal or genetic causes of recurrent spontaneous abortion. Methods: A cytogenetic study was made in of 921 couples for 13 year from January 1984 to December 1997 in which the woman was ascertained to have had two or more spontaneous abortions at our Cytogenetic Laboratory, Institute of Reproductive Medicine and Population, Seoul National University. Results: The overall incidence of chromosome anomaly was 80 out of 921(8.7%). There were 34 cases(3.69%) of reciprocal balanced translocation and 13 cases(1.41%) of Robertsonian translocation. Also 17 cases(1.85%) of inversion and 5 cases (0.54%) of X chromosome mosiacism was observed. In the case of reciprocal balanced translocation , chromosome 8,6,7,13 were preferentially involved over others. And in the case of Robertsonian translocation, chromosome 13 was preferentially involved. Conclusion: Our study demonstrates that cytogenetic analysis is indicated in couples with 2 or more spontaneous abortion and about half of these disorders are reciprocal balanced or Robertsonian translocations
키워드 : Recurrent spontaneous abortion, Cytogenetic study, Chromosome, Karyotype
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