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대한생식의학회지 제26권 제3호 2010년
인간의 자궁에서의 Luteinizing Hormone(LH) 유전자 발현
이화여자대학교 의과대학 의학과 및 의과학연구소 분자생물학부, 상명대학교 생물학과
김성례, 이성호,
Expression of Luteinizing Hormone(LH) Gene in Human Uterus
Kim sr, Lee sh
Recent studies, including our own, demonstrated that the novel expression of LH gene in rat gonads and uterus, indicating that the local production and action of the LH-like molecule. In the present study, we investigated whether human uterus also expresses the LH gene. Reverse transcription-polymerase chain reaction(RT-PCR) amplified the cDNA fragments coding LH polypeptide from human endometrium but not from myometrium. Presence of the transcripts for the α-subunit in human endometrium was also confirmed by RT-PCR. Transcripts for LH subunit were detected in endometrial samples from women with endometriosis. The gene for LH/hCG receptor was expressed in both endometrium and myometrium, showing good agreement with previous studies. Increased level of LH transcript was determined in the endometrium from follicular phase compared to that from luteal phase. Taken together, our findings demonstrated that 1) the genes for LH subunits and LH/hCG receptor are expressed in human uterus, 2) the uterine LH expression was changed during menstrual cycle, suggesting that the uterine LH may play a local role in the control of uterine physiology and function(s).
키워드 : LH and its receptor, Gene expression, Human uterus, Local regulator
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