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대한생식의학회지 제26권 제3호 2010년
Bromocriptine질투여로 치료된 프로락틴과다증 1례
포천중문의과대학 산부인과학교실
남윤성, 이우식, 박찬, 윤태기, 차광열,
A Case of Hyperprolactinemia Treated by Vaginal Bromocriptine Administration
Nam ys, Lee ws, Park c, Yoon tk, Cha ky
The clinical spectrum of prolactin – related infertility includes galactorrhea, amenorrhea, oligomenorrhea, luteal insufficiency, and possibly subtle follicular dysfunction, all of which occur as a result of hyperprolactinemia. These features are commonly encountered in women with primary disorders of prolactin metabolism, namely, prolactin – secreting pituitary tumors, or hyperprolactinemias. Idiopathic or functional hyperprolactinemia and the empty sella eyndrome are also included in this group. Bromocriptine, a dopamine agonist, has an established therapeutic role in the treatment of hyperprolactinemia, with or without a prolactin – secreting adenoma. However, the oral route of administration is associated in about 50 – 70% of patients with adverse side effects, most commonly nausea, vomiting, headache, and dizziness. Most of these reactions are mild and tend to occur in the early stages of therapy. However, as many as 10% of patients experience severe side effects requiring discontinuation of therapy. We have experienced a case of hyperprolactinea treated by vaginal bromocriptine administration which showed severe side effects via oral route. So we report this case with a brief review of literatures.
키워드 : Hyperprolactinemia, Vaginal bromocriptine
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