논문 및 학회지

대한생식의학회지   제27권 제3호 2010년

구형정자의 난자내 미세주입 후 보조활성화술에 의한 임신과 분만 1례

부산 마리아산부인과;부산 마리아산부인과;서울 마리아산부인과;서울 마리아산부인과;대구대학교 생물공학과;

주재홍;이용찬;윤산현;임진호;박흠대;,

A Normal Pregnancy and Delivery by Assisted Activation Following Roundheaded Spermatozoa (Globozoospermia) Injected into Oocytcs

Joo, Jae-Hong;Lee, Yong-Chan;Yun, San-Hyun;Im, Jin-Ho;Park, Heum-Dai;

Maria Infertility Clinic, Pusan;Maria Infertility Clinic, Pusan;Maria Infertility Clinic, Seoul;Maria Infertility Clinic, Seoul;Biotechnology, College of Engineering, Teagu University;

Globozoospermia is a rare type of teratozoospermia. It occurs in 0.1% of all andrological patient's and used to be considered sterile. Globozoospermic patient has 100% round headed spermatozoa, but the spermiogram is normal. The spermatozoa show oval-shape head, the lack of a nuclear envelope, acrosome, and post acrosomal sheath. Objective: To report that a couple with infertility secondary to globozoospermia received ICSI treatment. Material and Method: Case report Results: In the first trial, fertilization was failed. In the second trial, 40% of oocytes were fertilized and all of these embryos were cleaved, but pregnancy did not achieved. In the third trial, sperm injected oocytes were exposed to 10 ${\mu}M$ calcium ionophore for 15 min. All of the injected oocytes were fertilized and proceeded to develop. Triplet pregnancy was achieved after the transfer of six embryos in their third cycle. One embryo vanished and the remaining twins (female) were delivered at 33 weeks of gestation by Caesarean section. Conclusion: This result shows that assisted activation following ICSI may overcome infertility associated with globozoospermia.

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